Status:
COMPLETED
Physical Exercise in Normobaric Hypoxia and Normoxia in Type 1 Diabetic Patients
Lead Sponsor:
Silesian Centre for Heart Diseases
Collaborating Sponsors:
The Jerzy Kukuczka Academy of Physical Education in Katowice
Conditions:
type1diabetes
Eligibility:
MALE
30-45 years
Phase:
NA
Brief Summary
Physical activity, along with proper nutrition, is the basis for the behavioral treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes...
Detailed Description
Hypoxia leads to HIF-1 production (hypoxia inducible factor 1) which regulates expression of many genes (eg. gene responsible for erythropoetin production). It also stimulates angiogenesis, muscle hyp...
Eligibility Criteria
Inclusion
- type 1 diabetes of at least 10 years duration
- low physical activity
- BMI 20-30 kg/m2
- treated with multiple insulin injections (at least 4) or insulin pump (continuous subcutaneous insulin infusion \[CSII\])
- negative ECG exercise test
- HbA1c ≤ 8,0%
- high knowledge about functional insulin therapy, carbohydrate counting and diabetes management during exercise
- use of advanced glucometer functions and experience in use of Free Style Libre (Flash Glucose Monitoring System, Abbott)
Exclusion
- HbA1c \> 8,0%,
- advanced complications of diabetes \[pre-proliferative or proliferative retinopathy, and previous laser therapy, microalbuminuria or overt nephropathy, autonomic neuropathy (including lack of elevated heart rate during physical activity)\]
- patients physically active (regular physical activities more than once a week),
- positive ECG exercise test, history of cardiovascular event or coronary heart disease.
Key Trial Info
Start Date :
October 30 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2020
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04450745
Start Date
October 30 2019
End Date
September 30 2020
Last Update
April 28 2022
Active Locations (1)
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1
Department of Internal Diseases, Diabetology and Cardiometabolic Disorders, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland
Zabrze, Silesian Voivodeship, Poland, 41-800