Status:
UNKNOWN
CT-based Radiomic Algorithm for Assisting Surgery Decision and Predicting Immunotherapy Response of NSCLC
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Collaborating Sponsors:
Guangdong Provincial People's Hospital
Conditions:
Predictive Cancer Model
Lung Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study was to investigate whether the combined radiomic model based on radiomic features extracted from focus and perifocal area (5mm) can effectively improve prediction performance...
Detailed Description
Early detection and diagnosis of pulmonary nodules is clinically significant regarding optimal treatment selection and avoidance of unnecessary surgical procedures. Deferential pathology results cause...
Eligibility Criteria
Inclusion
- (a) that were pathologically confirmed as precancerous lesions or Stage I lung adenocarcinoma （≤3cm）
- (b) standard Chest CT scans with or without contrast enhancement performed \<3 months before surgery；
- (c) availability of clinical characteristics.
Exclusion
- (a) preoperative therapy (neoadjuvant chemotherapy or radiotherapy) performed,
- (b) suffering from other tumor disease before or at the same time.
- (c) Contain other pathological components such as squamous cell lung carcinoma (SCC) or small cell lung carcinoma (SCLC) or
- (d) poor image quality.
- Inclusion Criteria of immunotherapy cohort:
- (a) that were diagnosed as advanced NSCLC
- (b) Both standard Chest CT scans with contrast enhancement performed \<3 months before and after first dose of immunotherapy are available；
- (c) availability of clinical characteristics.
- Exclusion Criteria of immunotherapy cohort:
- (a) Ever receiving pulmonary operation on the same side of the lesion.
- (b) suffering from other tumor disease before or at the same time.
- (c) Contain other pathological components( SCLC or lymphoma) or
- (d) poor image quality.
- (e) incomplete clinical data.
Key Trial Info
Start Date :
August 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT04452058
Start Date
August 1 2019
End Date
December 30 2022
Last Update
June 30 2020
Active Locations (3)
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1
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China, 510000
2
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, China, 510000
3
Zhoushan Lung Cancer Institution
Zhoushan, Zhejiang, China, 316000