Status:
UNKNOWN
Furosemide Stress Test for the Prediction of Acute Kidney Injury Severity in Acute Heart Failure Patients
Lead Sponsor:
Chiang Mai University
Conditions:
Heart Failure
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Brief Summary
This study is aim to study the changes of serum creatinine levels at 72 hours after admission in patients with acute heart failure who has diuretic resistance compared to those who do not have diureti...
Detailed Description
This study is an observational prospective study to demonstrate a prognosis of acute heart failure patients who have diuretic resistance compared to those who do not have diuretic resistance from furo...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Diagnosis of acute heart failure which is defined by 2 of the 3 following features: ≥2+ leg edema, jugular venous pressure \>10 cm from physical examination or central venous pressure \>10 mmHg, and bilateral pulmonary edema or bilateral pleural effusion from chest radiography
- Patients consent to participate into the study
Exclusion
- Patients who receive furosemide ≥500 mg/day or hydrochlorothiazide ≥100 mg/day or spironolactone ≥100 mg/day or tolvaptan of any doses
- Patients who have systolic blood pressure \<100 mmHg or who need vasoactive drugs inotropic agents (except dobutamine)
- Patients with intravascular volume depletion from clinical evaluation
- Patients with chronic kidney disease stage 5 (estimated glomerular filtration rate \<15 ml/min/1.73 m2) or patients who receive maintenance dialysis
- Patients who require renal replacement therapy at the time of admission
- Patients whom diagnosed hypertrophic obstructive cardiomyopathy, severe valvular stenosis or complex congenital heart disease
- Patients with sepsis or systemic infection
- Pregnant women
- Patients who have history of furosemide, spironolactone or hydrochlorothiazide allergy
Key Trial Info
Start Date :
July 5 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2021
Estimated Enrollment :
257 Patients enrolled
Trial Details
Trial ID
NCT04464811
Start Date
July 5 2020
End Date
August 31 2021
Last Update
July 9 2020
Active Locations (1)
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1
Chiang Mai University Hospital, Faculty of Medicine, Chiang Mai University
Chiang Mai, Thailand, 50200