Status:
UNKNOWN
The Relationship Betweensarcopenia And Myosteatosis With The Natural History Of Liver Cirrhosis
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Sarcopenia
Sarcopenic Obesity
Eligibility:
All Genders
40-75 years
Brief Summary
Malnutrition is a common figure associated with liver cirrhosis. The main component of malnutrition in liver cirrhosis is represented by sarcopenia, a condition of a progressive and generalized loss o...
Detailed Description
Malnutrition is a common figure associated with liver cirrhosis with an incidence ranging from 5% to 99% of patients depending on the population studied and diagnostic tools used for the diagnosis \[A...
Eligibility Criteria
Inclusion
- all patients with liver cirrhosis (age 40 - 75 years) undergoing abdominal CT-scan including the third lumbar L3 vertebrae for the clinical indication (surveillance of focal liver lesions, vascular evaluation, pre-transplant evaluation, pre-TIPS evaluation.) will be considered for the enrollment.
Exclusion
- Active list for liver transplantation (LT) (patients at evaluation for LT will beenrolled);
- hepatocellular carcinoma HCC;
- previous LT or listing for multivisceral or living-related LT;
- concomitant neuromuscular disease;
- Patients with acute or subacute liver failure without underlying cirrhosis;
- Evidence of current malignancy except for non-melanocytic skin cancer;
- Presence or history of severe extra-hepatic diseases (e.g., chronic renal failure requiring hemodialysis, severe heart disease (NYHA III-IV); severe chronic pulmonary disease (GOLD \> III), severe neurological and psychiatric disorders);
- HIV-positive patients;
- Patients who decline to participate or who cannot provide prior written informed consent and when there is documented evidence that the patient has no legal surrogate decision maker and it appears unlikely that the patient will regain consciousness or sufficient ability to provide delayed informed consent;
Key Trial Info
Start Date :
July 10 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2022
Estimated Enrollment :
374 Patients enrolled
Trial Details
Trial ID
NCT04466709
Start Date
July 10 2019
End Date
January 1 2022
Last Update
July 10 2020
Active Locations (1)
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1
Gastroenterology Department, Sapienza University of Rome
Rome, Italy, 00100