Status:
RECRUITING
Comprehensive Genomic Profiling and Next Generation Functional Drug Screening for Patients With Aggressive Haematological Malignancies
Lead Sponsor:
Medical University of Vienna
Collaborating Sponsors:
Roche Pharma AG
Allcyte GmbH
Conditions:
Advanced Lymphoma
Refractory Lymphoma
Eligibility:
All Genders
18+ years
Brief Summary
EXALT-2 is a prospective, randomized, three arm study for treatment decision guided either by either comprehensive genomic profiling, next generation drug screening or physician's choice
Eligibility Criteria
Inclusion
- patient is suffering from aggressive haematological disease AND has undergone at least two lines of previous therapies AND/OR has undergone at least one previous therapy and no standard treatment is available in the specific disease setting and disease specific guidelines recommend treatment in studies.
- duration of last response is less than 6 months defined as first day of last treatment to date of relapse, the response duration has to be available with dates (dd/mm/yyyy) for initiation of and relapse to previous treatment.
- best response to previous treatment has to be available.
- The patient is able to give written informed consent and wishes to undergo further therapy
- further therapy is medically feasible
- tumor cell-containing samples can be obtained
Exclusion
- current participation in another experimental clinical trial
- performance status does not allow participation (ECOG ˃ 1)
- pregnancy, tested at screening
- patient suffers from classical or nodular, lymphocyte predominant Hodgkins lymphoma.
- other malignoma, diagnosed \<1a before inclusion (except localized squamous cell carcinoma of the skin, surgically curable melanoma of the skin, basal cell carcinoma of the skin)
Key Trial Info
Start Date :
June 10 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04470947
Start Date
June 10 2020
End Date
March 31 2026
Last Update
March 22 2024
Active Locations (1)
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1
Medical University of Vienna
Vienna, Austria, 1090