Status:
COMPLETED
High-dose vs. Standard-dose Cephalexin for Cellulitis
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborating Sponsors:
The Ottawa Hospital Academic Medical Association
Canadian Association of Emergency Physicians
Conditions:
Cellulitis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Cellulitis is a painful bacterial infection of the skin and underlying tissue that needs antibiotic treatment. There are approximately 193,000 visits to Canadian emergency departments (EDs) each year ...
Detailed Description
Background: Cellulitis is a common clinical condition that represents up to 3% of all emergency department (ED) visits. The current treatment failure rate is approximately 20%. This high treatment fai...
Eligibility Criteria
Inclusion
- Adults (age \>=18 years) with non-purulent cellulitis determined by the treating emergency physician to be eligible for outpatient care with oral antibiotics.
Exclusion
- Age \<18 years
- Patient already taking oral antibiotics
- Treating physician decides that intravenous therapy is required
- Abscess requiring an incision and drainage or needle aspiration procedure
- Known prior cellulitis secondary to methicillin-resistant Staphylococcus aureus
- Cellulitis secondary to a human or animal bite wound
- Surgical site infection
- Malignancy and currently being treated with chemotherapy
- Febrile neutropenia (temperature \>=38C plus absolute neutrophil count \<500 cells/uL)
- Solid organ or bone marrow transplant recipient
- Renal impairment with creatinine clearance \<30 mL/min
- Pregnant or breastfeeding
- Allergy to cephalosporins or history of anaphylaxis to penicillin
- Inability to provide consent
Key Trial Info
Start Date :
August 16 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 23 2022
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT04471246
Start Date
August 16 2021
End Date
February 23 2022
Last Update
January 17 2025
Active Locations (1)
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1
The Ottawa Hospital
Ottawa, Ontario, Canada, K1y 4E9