Status:
COMPLETED
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Parkinson Disease
Eligibility:
All Genders
50-80 years
Brief Summary
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity. Therefore, w...
Detailed Description
Parkinson's disease (PD) is a common progressive neurodegenerative disorder characterized by resting tremor, bradykinesia, restricted mobility, and postural instability. Early diagnosis of PD would be...
Eligibility Criteria
Inclusion
- \-
Exclusion
- Cardiac pacemaker or defibrillator implantation Intracranial metal device implantation
- Other major systemic diseases, such as renal failure, heart failure, stroke, AMI/unstable angina, poorly controlled diabetes mellitus, poorly controlled hypertension
- Alcohol or drug abuse
- Moderate to severe dementia
- Severe movement disorders
- Imaging data is similar to a nuclear medical examination, exclusion criteria is any abnormality that may affect cognitive function as reflected in computer tomography or MRI records, such as hydrocephalus or encephalitis. Mild cortical atrophy is acceptable.
- History of intracranial surgery including thalamotomy, pallidotomy, and/or deep brain stimulation
- Major physical or neuropsychiatric disorders
- Structural abnormalities that may cause dementia, such as cortical infarction, tumour, or subdural hematoma
- Besides medication for Parkinson's Disease, taking other medication with substances that can pass through the blood-brain barrier
- Besides medication for Parkinson's Disease, taking other medication for more than 10 years
- Treatments or concurrent illnesses other than Alzheimer's Disease that could interfere with cognitive function
- Meet the criteria for dementia (DSM-IV)
- Head trauma with loss of consciousness greater than 10 minutes
- Severe loss of sensation
Key Trial Info
Start Date :
August 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2020
Estimated Enrollment :
288 Patients enrolled
Trial Details
Trial ID
NCT04472325
Start Date
August 1 2017
End Date
July 31 2020
Last Update
August 6 2021
Active Locations (1)
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1
ChangGung Memorial Hospital, Linkou
Taoyuan District, Taiwan, 333