Status:
UNKNOWN
COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients
Lead Sponsor:
Ministry of Health, Kuwait
Conditions:
Moderate COVID-19 Pneumonia, Severe COVID-19 Pneumonia
Pneumonia, Viral
Eligibility:
All Genders
15-85 years
Phase:
PHASE1
Brief Summary
Due to the limitations of COVID-19 treatment and in the absence of licensed antiviral for COVID-19, the historical choice of therapeutic convalescent plasma (CP) is considered especially against RNA v...
Detailed Description
This is a prospective multicenter interventional observational study will be conducted in 4 major tertiary hospitals (Al-Sabah, Farwaniya , Mubarak Al-Kabeer and Jahra) in Kuwait .
Eligibility Criteria
Inclusion
- Patients aged ≥18 years old ( those who are younger are involved after case based discussion)
- Confirmed laboratory diagnosis with SARS-CoV-2 ,and admission diagnosis of SARS-CoV-2.
- Patients with moderate or severe COVID-19 (moderate COVID-19 disease defined as the presence of any signs of pneumonia (fever, cough, dyspnoea fast breathing) including SpO2 \>90 on room air , but no signs of severe pneumonia (severe pneumonia have the above plus one of the following: respiratory rates \>30 breaths/minutes or SpO2\<90% on room air), or admission to intensive care unit (ICU) for respiratory support (i.e.high flow nasal cannula, non-invasive mechanical ventilation and intubation).
Exclusion
- -Contraindication to transfusion (volume overload, history of anaphylaxis to blood products).
- \- Patients presenting with acute severe multiorgan failure, hemodynamic instability.
- 3- Severe disseminated coagulopathy (DIC), septic shock and those with expected survival of less than 48 hours.
Key Trial Info
Start Date :
May 21 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2020
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04474340
Start Date
May 21 2020
End Date
December 30 2020
Last Update
July 21 2020
Active Locations (1)
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1
Ministry Of Health
Kuwait City, Kuwait