Status:
RECRUITING
Sj-subway, a Predictor for the Recurrence of High-risk Hormone Receptor-positive Breast That is Sensitive to Extended Endocrine Therapy
Lead Sponsor:
Shengjing Hospital
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-70 years
Brief Summary
Hormone receptor-positive breast cancer accounts for about 70% of all breast cancers. Extended endocrine therapy with aromatase inhibitor is the current main treatment for hormone receptor-positive br...
Detailed Description
Breast cancer has been one of the most common malignant tumors in women, accounting for 23% of all the malignancies. There are estimated 1,300,000 new cases of breast cancers and 400,000 deaths due to...
Eligibility Criteria
Inclusion
- early-stage invasive breast cancer positive for estrogen receptor and / or progesterone receptor is pathologically confirmed;
- patients who have completed standard endocrine therapy for 5 years without recurrence and metastasis;
- 18-70 years old;
- patients with one of the following six manifestations: KI67 ≥ 30%; tumor size \> 2 cm; positive lymph nodes; histological grade III; vascular cancer thrombus; HER-2 gene overexpression or amplification.
Exclusion
- with a history of other malignancies;
- patients who have severe abnormalities in important organs, such as the heart, liver, and kidney or who cannot be tolerant to extended treatment due to poor constitution;
- patients with severe osteoporosis or dyslipidemia, or those who cannot tolerate endocrine therapy ;
- patients who have participated in other clinical trials.
Key Trial Info
Start Date :
July 19 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT04476485
Start Date
July 19 2021
End Date
December 31 2026
Last Update
July 20 2021
Active Locations (12)
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1
Cancer Hospital Affiliated to Harbin Medical University
Harbin, Heilongjiang, China, 150081
2
The Second Hospital of Jilin University
Changchun, Jilin, China, 130041
3
Dalian Municipal Central Hospital
Dalian, Liaoning, China, 116033
4
Panjin Liaohe Oilfield Gem Flower Hospital
Panjin, Liaoning, China, 124010