Status:
COMPLETED
Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients
Lead Sponsor:
Ain Shams University
Conditions:
End Stage Renal Disease on Dialysis
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
PHASE3
Brief Summary
To evaluate the effect of supplementation of vitamin K2 (menaquinone, MK-7)vs vitamin k1 on circulating levels of calcification regulators and to assess their safety in patients on regular dialysis pa...
Detailed Description
Vascular calcification has emerged as an independent risk factor for cardiovascular morbidity and mortality, especially in chronic kidney disease . It has a predictive value of poor prognoses and cli...
Eligibility Criteria
Inclusion
- Both sexes aged between 18-75 years
- Patients on HD greater than 3 months at least.
- Stable clinical condition (no hospitalization in the previous 3 months)
Exclusion
- Hypersensitivity to vitamin k
- Participant in an another clinical trial within the past 4 weeks.
- Judged to be unsuitable as a subject by the attending physician.
- Patients taking warfarin
- Patients with known intestinal malabsorption
- Patients with hypercoagulable state
Key Trial Info
Start Date :
July 25 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04477811
Start Date
July 25 2020
End Date
January 1 2021
Last Update
July 21 2021
Active Locations (1)
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1
Ainshams University
Cairo, Egypt, 02