Status:
NOT_YET_RECRUITING
Study of CD160, an Activating NK Cell Receptor, in Melanoma: a Potential Therapeutic Target?
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Melanoma
Eligibility:
All Genders
18+ years
Brief Summary
Although immunotherapy revolutionized melanoma outcomes over the last 10 years, only 40-50% of patients respond to treatments and 25% develop acquired resistances. Natural Killer (NK) cells naturally ...
Eligibility Criteria
Inclusion
- Inclusion Criteria :
- Patients aged18-years old or over
- ECOG score between 0-2
- Inoperable stage III or stage IV melanoma
- Naïve of treatment or in progression after one or several treatment lines
- Give their written consent for the present study and be included in MelBase cohort.
- health insurance coverage.
- Supplementary inclusion criteria for part II :
- skin or subcutaneous melanoma lesions
- agree and inform consent for a cutaneous biopsy or a tumor sample if presenting lymph nodes involvement if part of the usual clinical practice.
- Exclusion Criteria:
- Pregnant and breastfeeding women
- Patients with psychiatric disorders
- Patients already included in another clinical trial
- Having received chemotherapy or radiotherapy during the last 4 weeks,
- Patient presenting another solid or blood cancer, chronic viral infection (e.g. HIV, HBV or HCV)
- Been treated with more than 10mg of steroids until the 4 weeks before inclusion.
- Refusal to participate to the study
- Patients under guardianship or curatorship
- Patients on state medical aid
Exclusion
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 15 2027
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT04477876
Start Date
September 1 2020
End Date
December 15 2027
Last Update
July 20 2020
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