Status:
UNKNOWN
Deep Transcranial Magnetic Stimulation for the Treatment of Treatment Resistance Schizophrenia
Lead Sponsor:
Shanghai Mental Health Center
Conditions:
Deep Transcranial Magnetic Stimulation for the Treatment of Treatment Resistance Schizophrenia
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Based on the hypothesis that low-frequency deep transcranial magnetic stimulation(dTMS) on anterior cingulate cortex （ACC） could down-regulate the glutamate level of ACC and regulate the acc-related f...
Detailed Description
This study includes 20 treatment resistance schizophrenia patients and 20 healthy controls.This study will investigate 1)abnormalities of the glutamate level of ACC in patients with schizophrenia comp...
Eligibility Criteria
Inclusion
- Patients with schizophrenia who meet the dsm-5 diagnostic criteria
- Aged from 18 to 60
- After 4 weeks of treatment with a sufficient dose of an antipsychotic (equivalent dose of 400 \~ 600 mg/ day chlorpromazine (CPZ)), no clinical improvement was achieved (at least two items in PANSS scale P1,P2,P3,N1,N4,N6,G5 and G9 ≥4 points, or cgi-s ≥4 points)
- Right-handedness, normal hearing, visual acuity or corrected visual acuity
- Written informed consent of the patient and his/her family
Exclusion
- Patients who are currently taking clozapine or who have failed to respond to a full course of treatment with clozapine
- Current or past neurological illness,severe physical illness,substance abuse or addiction,alcohol dependence,mental retardation,pregnancy or lactation,extreme agitation, stupor, negative suicide,or those who can not cooperate
- A history of MECT within 6 months,or those with contraindications to MRI,rTMS
- Medically unstable for at least 1 month (PANSS score fluctuation\>10%)
Key Trial Info
Start Date :
July 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04478032
Start Date
July 5 2020
End Date
December 30 2022
Last Update
September 14 2021
Active Locations (1)
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1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030