Status:
RECRUITING
University of Iowa Interventional Psychiatry Service Patient Registry
Lead Sponsor:
Mark Niciu
Conditions:
Treatment Resistant Depression
Major Depressive Episode
Eligibility:
All Genders
18-99 years
Brief Summary
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include el...
Detailed Description
Treatment response biomarkers in TRD and OCD have been and will remain an active area of research. Interventional treatments in psychiatry, e.g. ECT, TMS, racemic ketamine infusions and intranasal esk...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- 18-99 years of age
- English-speaker with a level of understanding sufficient to agree to clinical treatment with a treatment modality offered by the Interventional Psychiatry Service, all required research procedures, and sign an informed consent document
- Clinical diagnosis of a major depressive episode in the context of major depressive disorder or bipolar disorder or treatment-resistant OCD evaluated by a provider on the Interventional Psychiatry Service and felt to be an appropriate candidate for clinical treatment with a treatment modality offered by the Interventional Psychiatry Service.
- EXCLUSION CRITERIA:
- Age less than 18 years
- A primary neuropsychiatric diagnosis that is not either major depressive disorder or bipolar disorder
- Serious, unstable medical conditions/problems including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease, e.g. uncontrolled asthma, uncontrolled hyper/hypothyroidism or active cancer.
- Involuntary commitment to psychiatry inpatient units
- If patients have one or more of the following MRI Exclusion criteria, they will not be able to participate in those aspects of this study:
- The presence of an implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible
- The presence of ferromagnetic objects in the body, i.e. bullets, shrapnel, and/or metal slivers
- Clinically-significant claustrophobia
- Clinically-significant hearing loss
- Pregnant or nursing women or women of child bearing potential not using at least one medically accepted means of contraception (to include oral, injectable, or implant birth control, condom or diaphragm with spermicide, intrauterine devices (IUD), tubal ligation, abstinence, or partner with vasectomy)
- The presence of any medical illness likely to alter brain morphology and/or physiology (e.g., hypertension, diabetes) even if controlled by medications
Exclusion
Key Trial Info
Start Date :
November 2 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2050
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT04480918
Start Date
November 2 2020
End Date
August 1 2050
Last Update
February 27 2025
Active Locations (1)
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1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242