Status:
COMPLETED
Blood Pressure Management in Stroke Following Endovascular Treatment
Lead Sponsor:
Hamilton Health Sciences Corporation
Conditions:
Stroke, Acute
Vessels; Occlusion
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The aim of DETECT is to prove the feasibility of a multicenter phase III trial testing the hypothesis that intensive blood pressure control immediately after successful endovascular stroke thrombectom...
Detailed Description
Current guidelines from the American Heart Association/ American Stroke Association (AHA/ ASA) propose thresholds of systolic blood pressure (BP) less than 180 mm Hg and diastolic BP less than 105 mm ...
Eligibility Criteria
Inclusion
- Age equal or more than 18 years.
- Eligible for endovascular treatment (EVT) within 24 hours from symptom onset according to current clinical practice.
- Presence of a proximal large vessel occlusion in the anterior circulation, defined as occlusion of the intracranial segment of the internal carotid artery and/or occlusion of the M1 segment or proximal M2 segment of the middle cerebral artery.
- Successful recanalization after the end of the EVT procedure, defined as modified thrombolysis in cerebral ischemia (mTICI) score equal or more than 2b.
- Sustained elevated systolic BP level after recanalization, defined as 2 consecutive systolic BP readings ≥ 150 mmHg (or ≥ 140 mmHg if the participant has a known history of hypertension) taken more than 5 minutes apart.
- Ability of the patient or legal representative to provide informed consent.
- Randomization within 60 minutes from the end of the EVT procedure.
Exclusion
- Presence of concomitant ipsilateral or contralateral extracranial vessel occlusion or remaining stenosis ≥80% after the end of the EVT.
- Symptomatic intracranial hemorrhage after the end of EVT procedure.
- Any medical condition where randomization to either standard or intensive BP lowering would not be acceptable at the discretion of the investigators and/or the treating physician.
- Pregnancy.
- Enrollment in another acute stroke therapeutic trial.
Key Trial Info
Start Date :
October 23 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 4 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04484350
Start Date
October 23 2020
End Date
May 4 2023
Last Update
November 7 2023
Active Locations (1)
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1
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L2X2