Status:
UNKNOWN
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
Lead Sponsor:
Vastra Gotaland Region
Collaborating Sponsors:
Göteborg University
Conditions:
Prosthetic Joint Infection
Prosthetic Infection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patie...
Detailed Description
In the infectious process, biofilms may form early on biomaterials. There is ample evidence to the several-fold increase in antimicrobial concentrations required to eradicate even immature biofilms. I...
Eligibility Criteria
Inclusion
- first PJI in hip or knee according to Musculoskeletal Infection Society (MSIS) definitions
- first DAIR
- mono-microbial staphylococcal infection
- 14 days of intravenous treatment with either cloxacillin or vancomycin
- standardized administration of local antibiotics
Exclusion
- allergy/previous toxic event/unacceptable drug interaction to most effective antibiotic combination according to either MIC or MBEC
- severe drug interactions to MBEC-guided compound
Key Trial Info
Start Date :
August 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04488458
Start Date
August 15 2021
End Date
December 31 2023
Last Update
August 24 2021
Active Locations (1)
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1
Ortopedi, Sahlgrenska University Hospital
Mölndal, Sweden