Status:
COMPLETED
4DX for the Diagnosis of Constrictive Bronchiolitis
Lead Sponsor:
Vanderbilt University Medical Center
Collaborating Sponsors:
4DMedical
Conditions:
Constrictive Bronchiolitis
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Constrictive bronchiolitis is an uncommon lung disease that has been described in Veterans of conflicts in Iraq and Afghanistan. Although these Veterans have evidence of constrictive bronchiolitis on ...
Detailed Description
Constrictive (or obliterative) bronchiolitis is a rare pulmonary disease characterized by subepithelial inflammatory and fibrotic narrowing of the bronchioles on histologic analysis, which often prese...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Constrictive bronchiolitis arm:
- Biopsy demonstrating constrictive bronchiolitis
- Prior CT Chest
- 18-60 years old
- \< 1 pack year history of tobacco use
- Control arm:
- 18-60 years old
- Prior CT Chest without evidence chronic lung disease as judged by a Pulmonologist
- No clinically significant dyspnea or functional limitations
- \< 1 pack year history of tobacco use
- Exclusion Criteria (for both arms)
- Pregnancy (as determined by testing on the morning prior to fluoroscopy)
- Inability to undergo PFTs or fluoroscopy
- Inability to raise arms above a 90-degree angle
Exclusion
Key Trial Info
Start Date :
June 25 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 27 2022
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04489758
Start Date
June 25 2021
End Date
May 27 2022
Last Update
August 30 2022
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232