Status:
UNKNOWN
Clinical Study on the Treatment of Mixed Component Cornea for High Risk Keratoplasty
Lead Sponsor:
Zhongshan Ophthalmic Center, Sun Yat-sen University
Conditions:
Corneal Transplantation
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Because of the immunologically privileged nature of the cornea, the graft rejection rate is less than 10% for low-risk keratoplasty. But when the cornea performed 2 or more quadrants of corneal neovas...
Detailed Description
Ocular trauma or infection lead to corneal limbal stem cell deficiency and central corneal opacification which could only be treated by central penetrating keratoplasty and limbal transplantation, but...
Eligibility Criteria
Inclusion
- Central corneal opacity involving full layer
- Corneal neovascularization in two or more quadrants
- Patients must be willing and able to return for scheduled follow-up examinations for 12 months after surgery
- Ages：18 -70 Years
Exclusion
- Central corneal opacity not involving the endothelial layer
- Less than two quadrants of corneal neovascularization
- History of Stevens-Johnson syndrome or Sjogren's syndrome
- Severe eyelid and conjunctival scar
- Loss of vision in contralateral eye
- Pregnant and lactating women
Key Trial Info
Start Date :
August 18 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04490902
Start Date
August 18 2020
End Date
July 1 2023
Last Update
February 24 2022
Active Locations (1)
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1
Zhongshan Ophthalmic Center, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510080