Status:
COMPLETED
Plasmatic Concentrations of Propofol and Remifentanil in Obese and Non Obese Patients.
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
General Anesthesia
Obesity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This prospective monocentric phamacokinetics study aims to compare plasmatic concentrations of Propofol and Remifentanil required to target a specific range of monitored anesthesia and analgesia durin...
Detailed Description
Remifentanil and Propofol are administered intravenously as an opioid pain reliever and hypnotic pain reliever during anesthesia. Their advantages are numerous: short half-life allowing anesthesia and...
Eligibility Criteria
Inclusion
- Obese patients group:
- Age ≥ 18 years old
- Severe and morbidly obese patients (35kg / m2≤IMC \<55kg / m2).
- Patients undergoing general anesthesia for laparoscopic susmesocolic surgery (bariatric surgery or cholecystectomy).
- Patients who have given their consent in the manner described by the public health law of August 9, 2004.
- Patients benefiting from a Social Security scheme.
- Group of non-obese patients:
- Age ≥ 18 years old
- Patients with normal weight or slightly overweight (19 \<BMI \<30).
- Patients receiving general anesthesia for laparoscopic susmesocolic surgery (cholecystectomy).
- Patients who have given their consent in the manner described by the public health law of August 9, 2004.
- Patients benefiting from a Social Security scheme.
Exclusion
- Patient refusal
- Age \<18 years old
- Protected adults and vulnerable persons
- Pace maker
- General anesthesia in the 24 hours preceding this surgery
- Proven or suspected dysautonomia
- Premedication by gabapentin Neurontin °
- Locoregional peri-medullary analgesia technique used concomitantly during the pre- and intraoperative period.
- Unbalanced dysrhythmic heart disease (AC / FA; extrasystoles; non-sinus rhythm)
- Pregnant or breastfeeding woman
- Intubation impossible planned
- Hypersensitivity to the products used
- Allergy to peanut or soy
Key Trial Info
Start Date :
December 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 25 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04492813
Start Date
December 20 2018
End Date
May 25 2021
Last Update
August 25 2021
Active Locations (1)
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1
Service d'Anesthésie-Réanimation, Pôle Médecine Périopératoire - Hôpital Estaing, CHU de Clermont-Ferrand
Clermont-Ferrand, Puy De Dôme, France, 63000