Status:
COMPLETED
Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors
Lead Sponsor:
Hvidovre University Hospital
Conditions:
Autonomic Dysfunction
Autonomic Imbalance
Eligibility:
MALE
30-45 years
Brief Summary
The function of the autonomic nervous system can be assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV). Decreased HRV has been shown to be predictive of morbidity and mortali...
Eligibility Criteria
Inclusion
- Volonteers eligable for blood donation following the Danish legislation
- Male
- Age 30-45
- Written informed consent
- Speak and understand Danish
Exclusion
- Volonteers not eligable for blood donation following the Danish legislation, among others due to:
- Alcohol and drug abuse
- Cognitive dysfunction
- Use of anxiolytic or antipsychotic drugs
- Arrhythmias or heart failure
- Diabetes mellitus type I
- Diabetes mellitus type II
- Use of opioids
- History of following diseases in the autonomic nervous system: Parkinson disease, multiple sclerosis, autonomic neuropathies
- History of cerebral apoplexy or transitory cerebral ischemia
- Dementia
- American Society of Anesthesiologists (ASA) score ≥ 4
- Furthermore:
- History of orthostatic intolerance and/or orthostatic hypotension
- Use of following vasodilator antihypertensive drugs: beta-blockers, angiotensin converting enzyme inhibitors (ACEI), angiotensin 2 receptor blockers (ARBs), calcium channel blockers
- Use of loop diuretics, thiazid diuretics and potassium-sparing diuretics
Key Trial Info
Start Date :
August 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2022
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04499664
Start Date
August 1 2020
End Date
June 1 2022
Last Update
August 30 2022
Active Locations (1)
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1
Hvidovre University Hospital
Copenhagen, Denmark, 2960