Status:
UNKNOWN
Estrogen Supplementation Mode in HRT-FET Cycle: a RCT
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions:
Hormone Replacement Therapy
Estrogen
Eligibility:
FEMALE
20-42 years
Phase:
NA
Brief Summary
A systematic review and meta-analysis concluded that there is insufficient evidence to recommend one particular protocol for HRT with regard to pregnancy rates after frozen embryo transfer, and no com...
Detailed Description
The objective is to compare between a constant estrogen dose protocol and a step-wise increasing estrogen dose protocol on live birth rate of HRT-FET cycles. This is a multicenter randomized controll...
Eligibility Criteria
Inclusion
- Women aged \<42 years at the time of HRT-FET
- Replacing 1-2 early cleavage embryos or blastocysts after thawing.
Exclusion
- Preimplantation genetic testing(PGT)
- Use of donor oocytes
- Hydrosalpinx shown on pelvic scanning and not surgically treated such as tubal ligation or resection
- Severe uterine adhesion
- The endometrial thickness cannot reach 8mm in previous fresh cycles or HRT -FET cycles
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
784 Patients enrolled
Trial Details
Trial ID
NCT04503915
Start Date
November 1 2020
End Date
December 1 2023
Last Update
August 7 2020
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