Status:
UNKNOWN
Different Anesthetic Strategies on Postoperative Cognitive Function and Delirium in Patients Undergoing Cardiac Surgery
Lead Sponsor:
China National Center for Cardiovascular Diseases
Collaborating Sponsors:
Tianjin Chest Hospital
The Second Hospital of Hebei Medical University
Conditions:
Delirium
Condition
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a prospective, multi-center, double-blind, randomized clinical trials.
Detailed Description
Prospective randomized multi-center trial involving about 502 subjects will be enrolled in 3 centers. Patients will be randomized to two groups in equal proportion. Investigators set a hypothesis that...
Eligibility Criteria
Inclusion
- Aged≥18 years;
- ASA:I to III;
- Hemodynamic stability, LVEF≥40%;
- Cardiac surgery including CABG, valve surgery, CABG combined with valve surgery, surgical repair of ASD,VSD and atrial myxoma, and other types.
Exclusion
- Declined to get involved;
- Emergency cases, heart transplantation;
- Severe hepatic insufficiency (Child-Pugh grades C),Severe renal insufficiency (requirement of renal replacement therapy);
- Previous history of drug and alcohol abuse,allergy to general anesthetics;
- Preoperative severe dementia, language barrier and mental illness
- Preoperative schizophrenia, epilepsy, stroke and Parkinson's disease
- Previous history of craniocerebral injury or neurosurgery;
- Any other conditions that are considered unsuitable for study participation.
Key Trial Info
Start Date :
September 11 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 18 2023
Estimated Enrollment :
502 Patients enrolled
Trial Details
Trial ID
NCT04505059
Start Date
September 11 2020
End Date
January 18 2023
Last Update
March 15 2022
Active Locations (3)
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1
The Second Hospital of HeBei Medical University
Shijiazhuang, Hebei, China, 050000
2
Fuwai Hospital, China National Center for Cardiovascular Diseases, CAMS&PUMC
Beijing, China, 100037
3
Tianjin Chest Hospital
Tianjin, China, 300222