Status:
TERMINATED
Management of Angiotensin Inhibitors During the Perioperative Period
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Surgery
Angiotensin Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in ...
Detailed Description
Rationale: Angiotensin inhibitors including angiotensin convertying enzyme inhibitors (ACEI), and angiontensin receptors blockers (ARB) are frequently used to treat patients with chronic hypertension...
Eligibility Criteria
Inclusion
- Chronic ACEI or ARB use for the treatment of hypertension. Patients who use a com-bination pill with a diuretic are eligible as well;
- Scheduled for elective intermediate to high risk noncardiac surgery, defined according to the European Society of Cardiology / European Society of Anesthesiology guidelines on noncardiac surgery;
- Expected postoperative length of stay of at least two days.
Exclusion
- Severe chronic kidney disease, defined as GFR\<30 ml/min/1.73 m2;
- ACEI/ARB use for the treatment of chronic systolic heart failure, defined as left ven-tricular ejection fraction ≤40%;
- ACEI/ARB use within one year after ST-elevated myocardial infarction, according to the fourth universal definition of myocardial infarction;
- Transplant surgery;
- ACEI/ARB use in a combination pill together with a drug other than a diuretic, including calcium channel blockers, beta-blockers and neprilysin inhibitors;
- Use of drugs acting on the renin-angiotensin-aldosterone system other than ACEI/ARB, e.g. aliskiren.
Key Trial Info
Start Date :
September 11 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2023
Estimated Enrollment :
342 Patients enrolled
Trial Details
Trial ID
NCT04506372
Start Date
September 11 2020
End Date
September 1 2023
Last Update
November 29 2023
Active Locations (7)
Enter a location and click search to find clinical trials sorted by distance.
1
University Health Network Toronto
Toronto, Ontorio, Canada
2
Amsterdam UMC location AMC
Amsterdam, Netherlands
3
Amsterdam UMC location VU
Amsterdam, Netherlands
4
Amphia Hospital
Breda, Netherlands