Status:
COMPLETED
Towards a Post-exposition Pharmacological Prophylaxis for Post-traumatic Stress Disorder
Lead Sponsor:
Psychiatric University Hospital, Zurich
Conditions:
Intrusive Thought
Psychological Trauma
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
In this study, we investigate the role that deep sleep plays in the prevention of posttraumatic stress disorder after someone has been exposed to a trauma by boosting deep sleep with two drug conditio...
Detailed Description
The present study seeks to investigate the potential to pharmacologically modulate slow-wave sleep in the acute aftermath of an experimentally-induced trauma in the interest of developing a secondary ...
Eligibility Criteria
Inclusion
- Speaks and understands German
- BMI 18.5 -\< 25
- Non-smoker status
- Habitual 5 or fewer alcoholic beverages / week
- Habitual 3 or fewer caffeinated beverages / day
- Habitual average sleep duration 7-9 h / night
- Normal or corrected-to-normal vision
- Insomnia Severity Index score between 8-14
Exclusion
- Travel across 3 or more time zones within 3 months of study start
- Habitual napping
- Extreme chronotype, determined by Morningness-Eveningness Questionnaire
- History of or presence of a trauma- or stressor-related disorder
- History of or presence of neurological disorder, psychiatric disorder or head injury
- History of or presence of a sleep disorder
- History of or presence of cardiovascular disorder
- Use of illicit drugs
- Atypical preference for excessively violent portrayals
- Faints at the site of blood or brutality
- Has participated in a study \< 30 days or a study such as this (i.e., experimental trauma) at all.
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 29 2022
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04508166
Start Date
October 1 2021
End Date
January 29 2022
Last Update
October 4 2022
Active Locations (1)
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1
University of Zurich
Zurich, Select An Option…, Switzerland, 8057