Status:
RECRUITING
Capturing MultiORgan Effects of COVID-19
Lead Sponsor:
University of Oxford
Conditions:
Coronavirus Infection
Multi-Organ Disorder
Eligibility:
All Genders
18-100 years
Brief Summary
The C-MORE study is prospective observational holistic longitudinal study which will characterise the prevalence of multi-organ injury among COVID-19 survivors post hospital discharge and assess its e...
Detailed Description
Since the outbreak of Coronavirus disease (COVID-19), hundreds of thousands of lives have been lost and millions significantly affected. Although primarily a respiratory viral illness, emerging data s...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged 18 years or above.
- Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase Chain Reaction (RT-PCR).
- Infection should be of moderate to severe intensity (i.e, patients with clinical signs of pneumonia such as respiratory rate \> 30 breaths/min; or severe respiratory distress; or SpO2 \< 90% (on room air) and admission for \>48 hours.
- Controls: Participants with no serological evidence of previous infection, or active/previous symptoms suggestive of COVID-19, and who may or may not have comorbidities.
Exclusion
- Contraindication to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia, inability to lie flat.
- Any other significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study.
- Any signs of active COVID-19 infection on day of visit.
- Significantly impaired renal function (eGFR\<30 ml/min)
Key Trial Info
Start Date :
May 13 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
750 Patients enrolled
Trial Details
Trial ID
NCT04510025
Start Date
May 13 2020
End Date
May 1 2026
Last Update
February 7 2025
Active Locations (1)
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1
University of Oxford
Oxford, United Kingdom, OX3 9DU