Status:
RECRUITING
Cardiovascular Responses to Exercise in People Living With HIV/AIDS: Effects of Exercise Training
Lead Sponsor:
Instituto Nacional de Cardiologia de Laranjeiras
Collaborating Sponsors:
Rio de Janeiro State University
Conditions:
HIV Infections
Eligibility:
All Genders
30-50 years
Phase:
NA
Brief Summary
Patients living with HIV (PLWHIV) have compromised muscle metaboreflex, which can cause exercise intolerance. This randomized controlled clinical trial will verify the effects of regular exercise on a...
Detailed Description
HIV-infection is associated to a reduced maximal cardiac output and blunted pressor reflex response to static handgrip exercise, which are suggestive of impaired ergoreflex activation. An abnormal erg...
Eligibility Criteria
Inclusion
- Inclusion Criteria for people living with HIV:
- diagnosis of HIv infection for at least 5 years;
- use of combined antiretroviral therapy for at least 3 years;
- asymptomatic and free from opportunistic diseases at enrollment.
- Exclusion Criteria:
- regular physical exercise;
- malnutrition;
- presence of coronary artery disease, ischemic diseases, pulmonary disease, diabetes, Chagas disease, tuberculosis, heart failure, hypertension;
- using pacemakers and/or antidepressant, antiarrhythmic or antihypertensive medication, especially beta-blockers.
Exclusion
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT04512456
Start Date
August 1 2024
End Date
December 31 2026
Last Update
April 30 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Rio de Janeiro State University
Rio de Janeiro, Rio de Janeiro, Brazil, 20550-900