Status:
ACTIVE_NOT_RECRUITING
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Lead Sponsor:
McMaster University
Conditions:
Proteomics
Exercise
Eligibility:
MALE
18-30 years
Phase:
NA
Brief Summary
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical i...
Eligibility Criteria
Inclusion
- Healthy males, between the ages of 18 and 30 y
- Body Mass Index between 18.5 and 30.0 kg/m2
- Able and willing to provide informed consent
Exclusion
- A history of neuromuscular disorders or muscle/bone wasting diseases.
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin-dependent or insulin-independent diabetes, or the presence of any other metabolic disease - all of which will be determined via a medical history screening questionnaire.
- The use of any medications known to affect protein metabolism (glucocorticoids, non-steroidal anti-inflammatory medication, or prescription strength acne medication, etc.).
- A (family) history of thrombosis.
- The use of anticoagulant medications.
- Consumption of tobacco-containing products.
- Excessive alcohol consumption (\>21 units/wk).
- History of bleeding diathesis, platelet or coagulation disorders, or anti-platelet/anticoagulation therapy.
- Exercise participation \>2 days/wk (structured resistance and/or aerobic-type exercise)
Key Trial Info
Start Date :
December 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04514744
Start Date
December 30 2021
End Date
July 1 2025
Last Update
October 2 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario, Canada, L8S 4K1