Status:
COMPLETED
Changes of Trace Elements in Aqueous Humor, Blood and Tears and Analysis of Related Factors
Lead Sponsor:
Zhongshan Ophthalmic Center, Sun Yat-sen University
Conditions:
Primary Glaucoma
Eligibility:
All Genders
18-80 years
Brief Summary
Trace elements are one of the indispensable substances in human body and play an important physiological role. Zinc is a trace element second only to iron in organisms, which is widely distributed in ...
Detailed Description
Glaucoma is a group of optic nerve diseases characterized by progressive and irreversible degeneration of retinal ganglion cells and their axons. There are different opinions on the pathogenesis of gl...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- \- If you meet the following conditions, you can participate in our study and become a subject in the case group:
- those who are over 50 years old and can complete all the examinations and examinations.
- other secondary and developmental factors have been excluded and diagnosed as primary glaucoma.
- before anti-glaucoma surgery, you can take part in blood sampling examination and collect sufficient tears, and sufficient aqueous humor can be collected during the operation.
- If you meet the following conditions, you can participate in our study and become a subject in the disease control group:
- those who are over 18 years old and can complete all the tests and examinations.
- other factors have been excluded and age-related cataract has been clearly diagnosed.
- before cataract surgery, you can take part in blood sampling examination and collect sufficient tears, and sufficient aqueous humor can be collected during the operation.
- If you meet the following conditions, you can participate in our study and become a normal control group:
- those who are over 50 years old and can complete all the tests and examinations.
- No previous history of ophthalmopathy (except ametropia, strabismus and age-related cataract).
- normal eye examination (intraocular pressure \< 21mmHg, chamber angle open, cup / plate ratio normal, visual field normal).
- can cooperate with those who take part in blood test and collect enough tears. -
- Exclusion criteria:
- those who have a history of eye trauma, eye surgery or eye laser.
- elevated intraocular pressure and glaucoma optic nerve damage caused by secondary or developmental factors (such as neovascularization, uveitis, trauma, lens-related factors, surgery, drugs, etc.).
- suffering from other eye diseases that may affect metabolism (such as uveitis, ocular neovascularization, age-related macular degeneration, etc.) and major systemic diseases (such as heart disease, hypertension, hyperlipidemia, diabetes, hepatitis, digestive tract malabsorption, hypothyroidism, vitamin deficiency, mental illness, severe psoriasis, malignant tumors, etc.).
- pregnant, lactating and pregnant women.
- those who refuse to sign the informed consent form due to discomfort or other reasons or voluntarily withdraw from the researcher.
- those who are unable to cooperate with the relevant inspection and inspection
Exclusion
Key Trial Info
Start Date :
August 20 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 20 2022
Estimated Enrollment :
167 Patients enrolled
Trial Details
Trial ID
NCT04515030
Start Date
August 20 2020
End Date
October 20 2022
Last Update
December 7 2022
Active Locations (1)
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1
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060