Status:
COMPLETED
Kharituwe TB Contact Tracing Study
Lead Sponsor:
Johns Hopkins Bloomberg School of Public Health
Collaborating Sponsors:
Perinatal HIV Research Unit of the University of the Witswatersrand
Setshaba Research Centre
Conditions:
Tuberculosis
Hiv
Eligibility:
All Genders
Up to 99 years
Phase:
NA
Brief Summary
The purpose of this study is to characterize the role of human mobility in fueling TB epidemics and estimate the potential impact of innovative case finding interventions tailored to mobile population...
Detailed Description
The investigators propose a randomized trial of two novel TB case-finding interventions among household members of patients diagnosed with active TB: holiday-based screening in a rural South African p...
Eligibility Criteria
Inclusion
- TB index cases:
- Inclusion criteria:
- Age 0-99 years (Including those recently deceased)
- Diagnosed with pulmonary TB at a study hospital or clinic (microbiological and/or chest x-ray diagnosis)
- Exclusion criteria:
- Unwilling/unable to provide informed consent (including next of kin, for those recently deceased)
- Plan not to pursue TB treatment within the study district
- Unwilling/unable to comply with study procedures
- Contacts:
- Inclusion criteria:
- Age 0-99 years
- Currently resides with or visiting eligible TB index case
- Exclusion Criteria:
- Unwilling/unable to provide informed consent
- Unwilling/unable to comply with study procedures
Exclusion
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2025
Estimated Enrollment :
10579 Patients enrolled
Trial Details
Trial ID
NCT04520113
Start Date
September 1 2020
End Date
March 31 2025
Last Update
April 8 2025
Active Locations (2)
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1
Perinatal HIV Research Unit (PHRU)
Johannesburg, South Africa
2
Setshaba Research Centre
Soshanguve, South Africa