Status:
RECRUITING
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Lead Sponsor:
Radboud University Medical Center
Conditions:
Postoperative Delirium
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
18+ years
Brief Summary
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic...
Detailed Description
Major (cardiovascular) surgery is frequently associated with cerebral dysfunction postoperatively. Major surgical procedures account for substantial systemic inflammatory activation. Interestingly, an...
Eligibility Criteria
Inclusion
- Competent patients ≥ 18 years
- Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.
Exclusion
- Patients with meningitis/encephalitis/brain abscess within the last 6 months
- Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more).
- Brain or spinal surgery within the last 3 months
- Active infection \<2 weeks before surgery
- Patients who object against storage of their body material for scientific reasons
Key Trial Info
Start Date :
December 18 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04523909
Start Date
December 18 2017
End Date
December 1 2026
Last Update
March 31 2023
Active Locations (1)
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1
Department of Intensive Care Medicine, Radboud university medical center
Nijmegen, Netherlands, 6500HB