Status:
UNKNOWN
iTBS Study for Depression in Patients With Multiple Sclerosis
Lead Sponsor:
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Multiple Sclerosis
Depression, Anxiety
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Multiple sclerosis (MS) is a chronic and demyelinating disease of the central nervous system. It is one of the most common cause of neurological disability in young adults. Depression is a common symp...
Detailed Description
Multiple sclerosis (MS) is a chronic and demyelinating disease of the central nervous system. It is one of the most common cause of neurological disability in young adults. Depression is a common symp...
Eligibility Criteria
Inclusion
- 1\) Age 18 to 65
- 2\) Male and female patients with clinically definite MS according to 2017 McDonald criteria
- 3\) EDSS 0 to 6
- 4\) Score between 11 and 30 on the Montgomery-Asberg Depression Rating Scale (MADRS) and stable antidepressants therapy \> 1 months before enrollment and during the follow-up period
- 5\) Informed consent of patients
Exclusion
- 1\) History of seizures (personal or family)
- 2\) Comedication with neuroleptics or tricyclic antidepressants
- 3\) bipolar disorder
- 4\) Presence of other diseases of the nervous system (history of stroke, brain injury, brain tumor, increased intracranial pressure)
- 5\) Significant neurologic, psychiatric, cardiovascular, hepatic, renal, gastrointestinal, metabolic, or other systemic comorbidities.
- 6\) History of drug or alcohol abuse
- 7\) Cardiac pacemakers
- 8\) Metal implants in the head
- 9\) Pregnancy
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04524039
Start Date
December 1 2020
End Date
December 31 2022
Last Update
November 24 2020
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