Status:
RECRUITING
EGb 761 in the Syndrome of MCI With Concomitant CVD
Lead Sponsor:
National Neuroscience Institute
Collaborating Sponsors:
Dr. Willmar Schwabe GmbH & Co. KG
Conditions:
Mild Cognitive Impairment
Cerebrovascular Disease
Eligibility:
All Genders
45-85 years
Phase:
PHASE2
Brief Summary
EGb 761 has been demonstrated to be useful in improving cognitive and global clinical outcomes in patients with cognitive impairment or dementia, when administered at a daily dosage of 240mg in random...
Detailed Description
EGb 761 has been demonstrated to be useful in improving cognitive and global clinical outcomes in patients with cognitive impairment or dementia, when administered at a daily dosage of 240 mg in rando...
Eligibility Criteria
Inclusion
- Patients who have been diagnosed with MCI based on the Petersen criteria and Albert MS criteria
- Patients who have a Global Clinical Dementia Rating Score of 0.5
- Patients aged 45 to 85 years at study entry
- Patients who are literate and able to complete the cognitive evaluations in the opinion of the investigators
- Patients with the presence of CVD, defined as the presence of white matter hyperintensities (WMH) of Fazekas grade 2 or 3 on MRI brain imaging (done up to 12 months prior to recruitment) or CT scans for patients contraindicated from MRI scans
- Patients who provide written informed consent to participate in the study
Exclusion
- Participants should not be receiving antidepressants, antipsychotics, benzodiazepines, acetylcholinesterase inhibitors or NMDA antagonists during the study. Additionally, contraindications for EGb 761 as given in the local prescribing information/Summary of Product Characteristics (SmPC) should be observed.
Key Trial Info
Start Date :
October 26 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
134 Patients enrolled
Trial Details
Trial ID
NCT04525144
Start Date
October 26 2020
End Date
November 1 2026
Last Update
November 17 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Neuroscience Institute
Singapore, Singapore, 308433