Status:
RECRUITING
Efficacy of Augmentation of Cognitive Behavioral Therapy With Transcranial Direct Current Stimulation for Obsessive-Compulsive Disorder (OCD)
Lead Sponsor:
Shanghai Mental Health Center
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study aims to evaluate the feasibility and clinical outcome of the Exposure-based Cognitive-Behavioral Therapy (CBT) concurrent with Transcranial Direct Current Stimulation (tDCS) in treating obs...
Detailed Description
The current study aims to evaluate feasibility and clinical outcome of exposure-based CBT（ERP）combined with tDCS over the prefrontal cortex (mPFC) in treatment of OCD patients. 60 OCD patients whose s...
Eligibility Criteria
Inclusion
- We recruited outpatient adults with OCD confirmed by the Mini-International Neuropsychiatric Interview (MINI). The following inclusion and exclusion criteria were also applied:
- (1) 18-50 years old, with at least 9 years of education, (2) Y-BOCS score ≥16, (3) no history of serious medical, neurological illness or other psychotic disorders other than OCD (anxiety or mild to moderate depression secondary to OCD was not exclusionary), (4) medication-free or had received stable medication for at least 2 months before entering the study and continued the same medication throughout the study (5) no previous exposure to ERP or tDCS.
Exclusion
- history of serious medical, neurological illness or other psychotic disorders other than OCD
- The inability to receive tDCS because of metallic implants, or history of seizures，or history of head injury, or history of neurosurgery.
- Participants who have received ECT, rTMS, tDCS and CBT in the past.
- Participants with claustrophobic, heart pacemaker, mechanical heart valve, mechanical implant such as an aneurysm clip, hip replacement, or any other pieces of metal that have accidentally entered their body.
- serious suicide risk
Key Trial Info
Start Date :
October 26 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 30 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04527302
Start Date
October 26 2020
End Date
August 30 2024
Last Update
April 16 2024
Active Locations (1)
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1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030