Status:
UNKNOWN
Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis
Lead Sponsor:
Indonesia University
Conditions:
Constipation
End Stage Renal Disease on Dialysis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of cons...
Detailed Description
One of the most common gastrointestinal symptoms in end-stage renal disease patients undergoing hemodialysis is constipation, which is one of the risk factors of microbiota dysbiosis. One effect of dy...
Eligibility Criteria
Inclusion
- Aged more than 18 years old
- Had undergone hemodialysis twice a week for a minimum of 3 months, with each visit lasting 5 hours
- Had only undergone hemodialysis therapy (not peritoneal dialysis/kidney transplantation)
- No history of malignancy or undergoing chemotherapy/radiation therapy
- No history of autoimmune disease or consuming immunosuppressants
- No history of bowel resection
- Had never been diagnosed with Crohn's disease or ulcerative colitis
Exclusion
- Patients whose hemodialysis schedule was changed from twice a week to three times a week
- Patients consuming prebiotics/probiotics/synbiotics within the past 3 weeks
- Patients experiencing infection or is consuming antibiotics
- Patients who are not willing to participate
Key Trial Info
Start Date :
September 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04527640
Start Date
September 15 2020
End Date
February 28 2021
Last Update
August 28 2020
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