Status:
COMPLETED
Methylene Blue and Postoperative Neurocognitive Disorders
Lead Sponsor:
Fudan University
Conditions:
Postoperative Delirium
Eligibility:
All Genders
55-80 years
Phase:
NA
Brief Summary
Postoperative Neurocognitive Disorders are the most common neurological complications after major surgery, which are associated with higher increased mortality and morbidity in elderly patients underg...
Detailed Description
Pancreatic cancer is one of the most common incident cancers that causes cancer death in China. The patients undergoing pancreatic cancer surgery not only have a low survival rate, but also have high ...
Eligibility Criteria
Inclusion
- aged 55-80 years old
- planning to undergo pancreatic tumor surgery.
- Patients have the ability to act in full spirit, understand and sign the informed consent, and are willing to complete the whole research process.
Exclusion
- preexisted dementia, major depression or other serious mental or neurological disorders
- history of allergy to MB or 6-phospho-glucose dehydrogenase deficiency (favism)
- MMSE\<24
- illiterate patients
- patients diagnosed with rheumatoid diseases such as systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis
- drug or alcohol abuse or recent drug administration that may lead to drug interactions, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)
- history of major head trauma
- serious medical diseases (ie. heart failure, pulmonary hypertension, acute stage of myocardial infarction or respiratory failure, hepatic and renal dysfunctions)
- severe language, visual or auditory deficiency
- other neoplastic diseases diagnosed in the past 5 years
- participated in other clinical trials within 3 months.
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2024
Estimated Enrollment :
314 Patients enrolled
Trial Details
Trial ID
NCT04529265
Start Date
May 1 2021
End Date
December 30 2024
Last Update
May 14 2025
Active Locations (1)
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1
Shanghai Cancer Center, Fudan University
Shanghai, China