Status:
UNKNOWN
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
Lead Sponsor:
University of Aberdeen
Conditions:
Anticholinergic Adverse Reaction
Eligibility:
All Genders
65-100 years
Phase:
NA
Brief Summary
Medications with anticholinergic properties are frequently prescribed for several conditions in older age; for example cardiovascular drugs (e.g. digoxin, furosemide), urologicals (e.g. darifenacin, o...
Eligibility Criteria
Inclusion
- Inclusion Criteria for stopping and/or switching medications
- Patients who are:
- aged 65 and over
- able to provide informed consent.
- on one or more long-term drugs (have been prescribed a minimum 6 weeks) with ACB potential (Anticholinergic Cognitive Burden scale ≥3) (defined according to Boustani et al (Boustani, Campbell et al. 2008)
- Exclusion Criteria for stopping and/or switching medications
- Patients who:
- are without capacity to provide informed consent.
- have severe mental illness \[such as diagnosis of severe anxiety, severe depression, severe dementia etc.\].
- are terminally ill (life expectancy less than 6 months).
- in opinion of responsible clinician are not suitable.
- are taking part in another study.
- Health care professional inclusion criteria for interviews
- \- Professionals: doctors (consultants, GPs), pharmacist in primary and secondary care involved in the care of patients aged 65 and over on polypharmacy regimes/likely to have anticholinergic burden and have taken part in the study by delivering the intervention
- Patients inclusion criteria for interviews
- \- Patients: patients aged 65 years and over who met eligible criteria and have taken part in the REGENERATE study will be selected.
- Exclusion criteria for interviews
- \- Participants who cannot understand English fluently
Exclusion
Key Trial Info
Start Date :
July 17 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04660838
Start Date
July 17 2021
End Date
February 28 2022
Last Update
September 14 2021
Active Locations (1)
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1
Peterculter Medical Practice
Aberdeen, United Kingdom, AB14 0RP