Status:
ACTIVE_NOT_RECRUITING
Real-time Neuromuscular Control of Exoskeletons
Lead Sponsor:
Shirley Ryan AbilityLab
Conditions:
Stroke
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this study is to develop a real-time controller for exoskeletons using neural information embedded in human musculature. This controller will consist of an online interface that anticip...
Detailed Description
The researchers will record muscle activity in healthy participants and participants post-stroke from up to eight lower limb muscles (soleus, gastrocnemius, tibialis anterior, rectus femoris, vastus l...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Healthy Participants:
- Age from 18 to 80 years
- No history of a brain and/or skull lesion
- Normal hearing and vision, both can be corrected
- Able to understand and give informed consent
- No neurological disorders
- Absence of pathology that could cause abnormal movements of extremities (e.g.,
- epilepsy, stroke, marked arthritis, chronic pain, musculoskeletal injuries)
- Able to understand and speak English
- Height between 3 foot 6 inches (1.1 meters) and 6 foot 9 inches (2.1 meters)
- Inclusion Criteria for Participants Post-stroke:
- Age from 18 to 80 years
- History of unilateral, supratentorial, ischemic or hemorrhage stroke greater than 6 months
- Ability to walk independently on level ground, allowed to use assistive device or bracing
- as needed
- Medically stable
- No planned surgeries, medical treatments or outpatient therapy during the study period
- Normal hearing and vision, both can be corrected
- Able to understand and give informed consent
- Able to understand and speak English
- Height between 3 foot 6 inches (1.1 meters) and 6 foot 9 inches (2.1 meters)
- Exclusion Criteria for Healthy Participants:
- Weight over 220 lbs
- Pregnancy (ruled out by pregnancy questionnaire)
- Any neurological diagnoses or medications influencing brain function
- History of significant head trauma (i.e., extended loss of consciousness, neurological
- sequelae)
- Known structural brain lesion
- Significant other disease (heart disease, malignant tumors, mental disorders)
- Non prescribed drug use (as reported by subject)
- History of current substance abuse (exception: current nicotine use is allowed)
- Recreational marijuana
- Dementia; severe depression; or prior neurosurgical procedures
- Failure to perform the behavioral or locomotor tasks
- Prisoners
- Exclusion Criteria for Participants Post-Stroke:
- Weight over 220 lbs
- Pregnancy (ruled out by pregnancy questionnaire)
- Botox (botulinum toxin) injection to lower limbs within the prior 3 months, or planned
- injection during study period.
- History of current substance abuse (exception: current nicotine use is allowed)
- Reduced cognitive function
- Severe aphasia
- Prisoners
- Co-existence of other neurological diseases (ex: (Parkinson's disease, traumatic brain
- injury, multiple sclerosis, etc.)
- Mixed or complex tremors
- Severe hip, or knee arthritis
- Osteoporosis (as reported by subject)
- Medical (cardiac, renal, hepatic, oncological) or psychiatric disease that would
- interfere with study procedures for HD-EMG
Exclusion
Key Trial Info
Start Date :
May 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04661891
Start Date
May 5 2021
End Date
December 1 2025
Last Update
May 25 2025
Active Locations (1)
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1
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611