Status:
COMPLETED
A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD)
Lead Sponsor:
Airway Therapeutics, Inc.
Conditions:
Bronchopulmonary Dysplasia
Eligibility:
All Genders
Up to 96 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine if an investigational drug, AT-100, can reduce the occurrence of Bronchopulmonary Dysplasia (BPD) in babies born premature, as compared to babies born prematu...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Preterm neonates born between Gestional Age (GA):
- 25 0/7 weeks to 28 6/7 weeks in the initial dose escalation cohorts.
- 23 0/7 weeks to 28 6/7 weeks in the latter cohort.
- Intubated and on mechanical ventilation.
- Receiving at least 1 dose of standard-of-care-indicated surfactant treatment (Curosurf®) after birth, and able to receive the first dose of AT-100 or air-sham within 96 hours of birth given at any time point after 15 minutes following any of the subject's Curosurf® dose(s).
- Parent or legal guardian is able to provide informed consent.
- Exclusion Criteria:
- Weight at time of birth \< 400 g or \> 1,800 g.
- Major apparent congenital abnormalities impacting cardio and pulmonary function.
- Active DNR (Do Not Resuscitate) order in place.
- Known pulmonary air leaks (e.g. pneumothorax and pneumomediastinum) at the time of AT-100 or air-sham administration.
- History of allergy or sensitivity to any surfactant or any component of the Investigational Product (AT-100).
- AT-100 or air-sham dosing was set to occur before Data Safety Monitoring Committee recommendation to proceed to the next dose-escalation cohort.
- Use of minimally invasive surfactant techniques (e.g., LISA, MIST) or INSURE or if, in the opinion of the care team, the infant is very likely too be extubated shortly after receiving Curosurf®.
- a. Subjects extubated and re-intubated after their Curosurf® dose(s) are eligible, so long as the subject meets Inclusion #3.
- Birth mother:
- Has known active Hepatitis B, C, or E diagnosis.
- Has a known illness or exposure that, in the judgement of the Investigator, is serious enough to induce an immune deficiency such as Human Immunodeficiency Virus (HIV) and/or is receiving chemotherapy.
- Has known active Sexually Transmitted Infection (STI).
- Has known Cytomegalovirus (CMV) active infection.
- Has known history or evidence of alcohol or drug abuse, wit the exception of marijuana/marijuana-based products/THC, based on a positive maternal or infant drug screen as evidenced by the institution's standard-of-care practice.
- Concurrent enrollment in an investigational drug, device, or treatment modulation trial that utilizes treatments outside of standard-of-care.
- Any condition or situation which, in the Investigator's judgement, puts the mother or the neonate at significant risk, could confound the trial results, or may interfere significantly with the mother's or neonate's participation in the trial.
- Symptomatic and confirmed COVID-19 infection of the mother around the time of birth.
Exclusion
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 29 2024
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT04662151
Start Date
September 1 2021
End Date
May 29 2024
Last Update
July 3 2024
Active Locations (19)
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1
Airway Therapeutics Investigational Site
Tucson, Arizona, United States, 85724
2
Airway Therapeutics Investigational Site
Little Rock, Arkansas, United States, 72202
3
Airway Therapeutics Investigational Site
Los Angeles, California, United States, 90017
4
Airway Therapeutics Investigational Site
Miami, Florida, United States, 33143