Status:
COMPLETED
Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy
Lead Sponsor:
University of Texas at Austin
Conditions:
Claustrophobia
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study evaluates whether a scent applied during exposure therapy and during subsequent sleep will increase the durability of treatment effects for individuals with fear of spiders, contamination, ...
Detailed Description
Newly acquired memories encoded during wakefulness are spontaneously re-activated during sleep, resulting in synaptic potentiation and strengthening of the re-activated traces. Targeted memory reactiv...
Eligibility Criteria
Inclusion
- Marked anxiety in at least one fear domain (spiders, contamination, or enclosed spaces), as determined by the presence of both:
- self-reported peak anxiety of at least 50 on a 100 point scale in response to two behavioral approach tasks
- self-report measures meeting the following cutoffs for the target fear:
- Fear of Spiders Questionnaire ≥ 50
- Obsessive-Compulsive Inventory-Revised (Washing Subscale) ≥ 4
- Claustrophobia Screener ≥ 2
Exclusion
- Diagnosed sleep disorder
- Current sleep medication usage
- Inability to differentiate two different odors from an indoor scent diffuser
- Current psychotherapy for fear of spiders, snakes, enclosed spaces, or contamination
- Current use of air fresheners, scented candles, or other items with odors related to those used in the study
Key Trial Info
Start Date :
January 29 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2020
Estimated Enrollment :
158 Patients enrolled
Trial Details
Trial ID
NCT04663672
Start Date
January 29 2019
End Date
March 1 2020
Last Update
December 11 2020
Active Locations (1)
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1
Laboratory for the Study of Anxiety Disorders, University of Texas at Austin
Austin, Texas, United States, 78712