Status:
RECRUITING
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)
Lead Sponsor:
Hui-Sheng Chen
Conditions:
Ischemic Stroke
Neuroprotection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who missed recanalization operation.
Eligibility Criteria
Inclusion
- Age ≥18 years;
- Major neurologic deficits: 6≤NIHSS≤20;
- Missing recanalization therapy (IVT or EVT) or progressive stroke, which was defined as symptoms worsen in 48 hours (an increase in NIHSS more than 4);
- Premorbid mRS 0 or 1;
- Signed informed consent.
Exclusion
- Modified Rankin Score \>2 caused by a history of prior stroke;
- Patients who underwent intravenous thrombolysis or Endovascular treatment;
- Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ \<80000/mm3;
- Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
- Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
- Unsuitable for this clinical studies assessed by researcher.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04664946
Start Date
December 1 2020
End Date
May 1 2026
Last Update
August 21 2025
Active Locations (1)
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1
Department of Neurology, General Hospital of Northern Theater Command
Shenyang, China, 110016