Status:
UNKNOWN
Diagnostic Accuracy of CCTA-derived Versus AngiogRaphy-dErived QuantitativE Flow Ratio (CAREER) Study
Lead Sponsor:
Fudan University
Collaborating Sponsors:
Shanghai Jiao Tong University -Pulse Medical Imaging Technology Joint Lab
Conditions:
Coronary Stenosis
Hemodynamics
Eligibility:
All Genders
35-85 years
Brief Summary
To perform CT-QFR, invasive coronary angiography, FFR, and QFR tests on patients with moderate coronary stenosis after coronary CTA examination. Use FFR as a reference to verify the diagnostic perform...
Detailed Description
This study is a prospective and single-center trial in China.It intends to enroll 216 patients with coronary artery disease whose coronary artery is determined to be 30-90% stenosis after coronary CT ...
Eligibility Criteria
Inclusion
- Coronary CT angiography indicates that \>= 1 stenosis with percent diameter stenosis between 30%-90% in a vessel \>= 2mm.
- The invasive coronary angiography should be less than 30 days after the coronary CT angiography.
Exclusion
- The target lesion has received coronary stent implantation or coronary artery bypass graft.
- Target lesion involves myocardial bridge.
- Severe heart failure (NYHA ≥III).
- Renal function is seriously damaged (eGFR\<30 ml/min/1.73m2).
- Those who are contraindicated to use contrast agents, beta blockers, nitrates or adenosine drugs.
- Acute myocardial infarction within 1 month.
- The image quality of CTA or coronary angiography cannot be assessed.
- Any factors that affect the image quality of coronary CTA and coronary angiography, such as frequent premature contractions, atrial fibrillation, etc.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
216 Patients enrolled
Trial Details
Trial ID
NCT04665817
Start Date
October 1 2020
End Date
December 31 2022
Last Update
January 25 2022
Active Locations (1)
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1
Xinkai Qu
Shanghai, Shanghai Municipality, China, 200040