Status:
COMPLETED
Safety and Immunogenicity Study of AdCLD-CoV19: A COVID-19 Preventive Vaccine in Healthy Volunteers
Lead Sponsor:
Cellid Co., Ltd.
Conditions:
COVID-19
Eligibility:
All Genders
19-64 years
Phase:
PHASE1
PHASE2
Brief Summary
This is a Phase 1/2a clinical trial to assess the safety and immunogenicity of AdCLD-CoV19 in healthy adults.
Detailed Description
Part A is conducted as dose-escalation, single-center, open-label, a Phase 1 clinical trial. Part B is conducted as multi-center, open-label, a Phase 2a clinical trial. In Part A, we assess safety in ...
Eligibility Criteria
Inclusion
- Able and willing to agree informed consent and aged 19 to 64 years.
- The BMI index is 18.5 kg/m2 to 30.0 kg/m2.
- Weigh 40kg to 100kg (Part A only)
- Able and willing to medically effective contraception during the whole study period.
- Agreement to refrain from blood donation during the whole study period.
Exclusion
- Anyone deemed infected by COVID-19.
- Determined to be a close-contact of SARS-CoV-2 confirmed case or classified to symptomatic patient of COVID-19 prior to vaccination.
- Clinically significant abnormal ranges of laboratory measurement, ECG, Chest X-ray at screening visit.
- Positive in HIV, HBV, HCV test at screening visit.
- Acute fever(≥ 38℃) or suspected infectious disease, symptoms of infectious disease(cough, difficulty breathing, chills, muscle aches, headache, sore throat, loss of smell, or loss of taste, etc.) within 3 days prior to vaccination.
- Chronic respiratory disease: Asthma, chronic obstructive pulmonary disease, active tuberculosis, latent tuberculosis under treatment.
- Clinically significant active or any history of disease: Hepatobiliary system, kidney, central or peripheral nervous system (epilepsy, seizure, etc.), endocrine system (uncontrolled diabetes, hyperlipidemia, etc.), cardiovascular system (congestive heart failure, coronary artery disease, myocardial infarction, control Hypertension, etc.), blood tumor, urinary system, mental, musculoskeletal system, immune system (rheumatoid arthritis, systemic lupus erythematosus).
- Immunosuppressive disease including immunodeficiency disease.
- Scheduled to undergo any surgery during the whole study period.
- Healthcare worker who provide medical care to SARS-CoV-2 cases or occupationally in high risk for SARS-CoV-2 exposure during the whole study period.
- Prisoners or subjects who are compulsorily detained. (involuntary incarceration)
- History of SARS or MERS.
- Allergic reaction or hypersensitivity to any ingredient of AdCLD-CoV19.
- Having hemophilia at risk of causing serious bleeding when injected intramuscularly or receiving anticoagulants.
- Any history of malignant disease within the past 5 years.
- History of hypersensitivity to inoculate vaccine such as Guillain-Barre syndrome.
- History of serious adverse reaction or allergic reaction to inoculate vaccine.
- Urticaria past 5 years prior to vaccination.
- History of hereditary angioneurotic edema or acquired angioneurotic edema.
- History of solid organ or bone marrow transplantation.
- Suspected or a history of drug or alcohol abuse past 12 month before vaccination.
- Receipt of vaccine of SARS-CoV, MERS-CoV, SARS-CoV-2.
- Receipt of adenovirus vector based vaccine.
- Chronic use of immunosuppressant or immune modifying drug within 6 months prior to vaccination. (use of inhaled, topical, nasal, and ophthalmic corticosteroids are allowed)
- Having relied on antipsychotic drugs and narcotic analgesics within 6 months before vaccination or difficult to comply with the clinical trial procedure at the judgment of the investigator.
- Administered to other investigational product or medical device within 6 months before vaccination.
- Other vaccination history within 30 days prior to vaccination or being scheduled within 30 days after vaccination.
- Receipt of immunoglobulin or any blood product within 3 month prior to vaccination.
- Pregnant(including positive hCG test at screening visit) or breastfeeding female.
- Current smoker or vaper. (use of cigarette or e-cigarette at least once in last 30 days, Part A only)
- Those who are directly related to the investigator.
- Other condition deemed ineligible for the study at the discretion of investigator.
Key Trial Info
Start Date :
December 29 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 27 2023
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04666012
Start Date
December 29 2020
End Date
March 27 2023
Last Update
July 28 2023
Active Locations (5)
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1
Korea University Ansan Hospital
Ansan, Province, South Korea
2
The Catholic University of Korea, ST. Vincent's Hospital
Suwon, Province, South Korea
3
Hallym University Kangnam Sacred Heart Hospital
Seoul, State, South Korea
4
The Catholic University of Korea, Seoul ST. Mary's Hospital
Seoul, State, South Korea