Status:
UNKNOWN
Clinical and Metabonomics Study on the Treatment of Heart Failure After Myocardial Infarction With Modified Wenxin Decoction
Lead Sponsor:
Jun Li
Conditions:
Heart Failure
Myocardial Infarction
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
To elucidate the efficacy and safety of weixin decoction in the treatment of heart failure after myocardial infarction.
Detailed Description
To elucidate the long-term protective effect of flavored Wenxin Decoction on heart failure after myocardial infarction. To elucidate the effective components in the treatment of heart failure and the...
Eligibility Criteria
Inclusion
- 18-75 years old；
- A history of acute myocardial infarction；
- Cardiac function Ⅱ - Ⅲ level；
- LVEF 50% or less;
- Nt-probnp level ≥ 450 pg/ mL；
- All men and women can sign the informed consent form.
Exclusion
- Coronary artery bypass grafting was performed within 12 weeks；
- Undergo or possibly undergo cardiac resynchronization therapy;
- Primary valvular disease, left ventricular outflow tract obstruction, myocarditis, aneurysm, uncontrolled severe arrhythmia, cardiogenic shock, unstable angina pectoris, or acute myocardial infarction;
- Having a serious primary liver, kidney or blood system disease or having a serious mental illness or a systemic disease that is out of control;
- Serum creatinine \> 194.5 mol/L or serum potassium \> 5.5mmol /L;
- The level of alanine aminotransferase or alkaline phosphatase is 1.5 times of the normal upper limit of \>;
- Abnormal blood pressure control, systolic blood pressure exceeding 180mmHg or diastolic blood pressure exceeding 110mmHg;
- Pregnancy or lactation; Known or suspected allergy to research drugs; To receive another investigational drug within 30 days of randomization or to be unwilling or unable to provide written consent.
Key Trial Info
Start Date :
December 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04667598
Start Date
December 15 2020
End Date
June 30 2023
Last Update
December 14 2020
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