Status:
RECRUITING
Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
Lead Sponsor:
University of Zurich
Conditions:
Brain Blood Flow Impairment
Eligibility:
All Genders
18+ years
Brief Summary
Primary study objective: • Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort. Secondary stud...
Detailed Description
Primary study objective: • to study the longitudinal observation of brain blood flow changes in neurosurgical patients to evaluate the effect of surgical or conservative treatment on the brain struct...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Patients:
- Male and Female subjects \>18 years of age
- Written informed consent after participants' information. Foreign speaking patients should be accompanied by a person with sufficient German language proficiency to act as a translator
- Neurosurgical diseases with the potential to alter blood flow to the brain:
- Cerebrovascular disease
- Brain tumors
- Normal Pressure Hydrocephalus
- Healthy subjects:
- Male and Female subjects \>18 years of age
- Written Informed Consent by the participant after information about the project. Foreign speaking healthy subjects should be accompanied by a person with sufficient German language proficiency to act as a translator
- Exclusion criteria:
- Patients:
- Unwilling or unable to co-operate with breathing maneuvers
- Respiratory or cardiac limitations to breathing through a mask
- Medical contra-indications to limited hypercapnia (high CO2 - 50 mmHg) or hypocapnia (low CO2 - 30 mmHg) (i.e., known increased intracerebral pressure, metabolic acidosis or alkalosis)
- Standard contraindications for MRI scanning
- Verbal confirmed pregnancy
- Known multiple intracranial diseases
- Presence of intracranial hemorrhage within the last 3 months
- Symptomatic increased intracranial pressure
- Healthy subjects:
- Unwilling or unable to co-operate with breathing maneuvers
- Respiratory or cardiac limitations to breathing through a mask
- Medical contra-indications to limited hypercapnia (high CO2 - 50 mmHg) or hypocapnia (low CO2 - 30 mmHg) (i.e., known increased intracerebral pressure, metabolic acidosis or alkalosis)
- Standard contraindications for MRI scanning
- Verbal confirmed pregnancy
- Anamnesticly a history of neurological disease or current neurological deficits.
Exclusion
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04668261
Start Date
January 1 2021
End Date
November 1 2027
Last Update
December 29 2020
Active Locations (1)
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1
University Hospital Zurich
Zurich, Switzerland, 8032