Status:
COMPLETED
Host RNA Signature in Children With Cancer and Infection
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
Børnecancerfonden
Lundbeck Foundation
Conditions:
Childhood Cancer
Infection
Eligibility:
All Genders
Up to 17 years
Brief Summary
The aim is to investigate if RNA expression signature can discriminate bacterial from viral infection or non-infectious inflammation in children with cancer. Earlier studies in immunocompetent childr...
Detailed Description
Children with cancer are at high risk of invasive bacterial infections particularly during neutropenia. Febrile neutropenia is an early sign of a potentially fatal infection requiring broad-spectrum e...
Eligibility Criteria
Inclusion
- Children with cancer and fever. Fever defined as temperature above 38.5 °C measured once, or 38.0-38.5 °C for ≥ 1 hour.
Exclusion
- The children can be excluded if they turn out to have a different diagnosis than expected or if it is not possible to draw the blood tests.
Key Trial Info
Start Date :
June 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2021
Estimated Enrollment :
370 Patients enrolled
Trial Details
Trial ID
NCT04669418
Start Date
June 1 2019
End Date
July 31 2021
Last Update
December 22 2022
Active Locations (5)
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1
Department of Pediatrics, Aalborg University Hospital
Aalborg, Denmark, 9000
2
Department of Pediatric Oncology, Aarhus University Hospital
Aarhus, Denmark, 8200
3
Center for Genomic Medicine
Copenhagen, Denmark, 2100
4
Department of pediatric and adolescent medicine, Rigshospitalet (Copenhagen University Hospital)
Copenhagen, Denmark, 2100