Status:
NOT_YET_RECRUITING
Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Bone Loss
Eligibility:
All Genders
18-99 years
Brief Summary
This study is seeking to evaluate the binding of a commercially-available, recombinant human osteoinductive growth factor, rhBMP-2, to a human blood derived product scaffold, enhanced Platelet-rich fi...
Detailed Description
Innovations in biomedicine and recombinant protein technology show promising advances for the regeneration of advanced alveolar defects. Recombinant growth factors and biologics encourage minimally in...
Eligibility Criteria
Inclusion
- English speaking
- At least 18 years old
- Must be a patient of the UAB Dental School
- Able to read and understand informed consent document
- Previously treatment planned for a periodontal procedure that will utilize PRF, i.e. requiring venipuncture, as a part of the routine clinical care.
Exclusion
- Non-English speaking
- Less than 18 years old
- Smokers/tobacco users (\>10 cigarettes/day)
- Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing as assessed by Board Certified Periodontal faculty at UAB Department of Periodontology
- Patient-reported serious adverse events reported with venipuncture, blood sample collection, and/or blood donation.
Key Trial Info
Start Date :
April 1 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04670965
Start Date
April 1 2026
End Date
July 1 2028
Last Update
December 15 2025
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294-0007