Status:
COMPLETED
Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma
Lead Sponsor:
Queen Mary University of London
Conditions:
Churg-Strauss Syndrome
Eosinophilic Asthma
Eligibility:
All Genders
18+ years
Brief Summary
In this project the investigators will look for auto-antibodies to relevant proteins both in native form and importantly in post-translationally modified forms. Potential modified auto-antigens are eo...
Detailed Description
The investigators will approach the research question with parallel agnostic and targeted approaches. In the agnostic approach the presence of auto-antibodies in patient serum and sputum to inactive ...
Eligibility Criteria
Inclusion
- Severe Eosinophilic Asthma (with multi-disciplinary diagnosis as per ERS/ATS Criteria, blood eosinophils ≥ 0.3 x109/L on inhaled corticosteroids); or
- EGPA (as per American College of Rheumatology (ACR) Criteria); or
- Eosinophilic COPD (post-bronchodilator FEV1/FVC \< 70% predicted, absence of bronchodilator reversibility, \> 20 pack year smoking history, no history of asthma, blood eosinophils ≥ 0.3 x109/L); or
- Eosinophilic oesophagitis (with diagnostic histology); or
- Granulomatosis with Polyangiitis (GPA, formerly called Wegener's) (as per American College of Rheumatology (ACR) Criteria)
Exclusion
- Known Pregnancy
- Anaemia
- Hepatitis B Virus, Hepatitis C Virus or HIV infection
- Donation of more than 240mls blood in the last sixteen weeks (four months) to any other research study or as a donation to the National Blood Transfusion Service
- Rituximab, plasmapharesis or polyclonal immunoglobulin infusion (ever)
Key Trial Info
Start Date :
December 10 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 5 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04671446
Start Date
December 10 2020
End Date
May 5 2024
Last Update
January 30 2025
Active Locations (2)
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1
Barts Health NHS Trust, Dept of Rheumatology, Mile End Hospital
London, United Kingdom, E1 4DG
2
Barts Health NHS Trust, Dept of Respiratory Medicine, St Bartholomew's Hospital
London, United Kingdom, EC1A 7BE