Status:
COMPLETED
Dinner Time 2: Effect of Delayed Eating or Sleeping on Metabolism
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
University of Arkansas
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Healthy
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
This study examines the acute impact of eating an "early" versus "late" dinner. "Early" and "late" will be customized to individuals based on the individuals' own circadian rhythms. Healthy adults wil...
Detailed Description
Obesity is a worldwide health problem. Recent studies suggest that the timing of meals may be critically important for weight control and cardiovascular health. Consuming calories later in the day is ...
Eligibility Criteria
Inclusion
- Inclusion:
- Healthy male and female adult volunteers, age 18-30
- BMI 18-30 kg/m2
- Accustomed to a bedtime before 1:00 A.M. or having mid-sleep on free days (MSF) earlier than 5 A.M. from the Munich Chronotype Questionnaire (MCTQ) (to exclude extreme late chronotypes)
- Exclusions:
- Sleep disorder including insomnia, sleep apnea, circadian rhythm disorder, restless leg syndrome, narcolepsy, shift work sleep disorder
- Gastroesophageal reflux disease that affects ability to tolerate a dinner close to bed time.
- Chronic use of sedative hypnotics, anxiolytics, opiates
- Use of medications that can affect circadian rhythm (beta blockers, melatonin)
- Active smoking (may interfere with metabolism and Clinical Research Unit (CRU) activities)
- Diabetes (type 1 or 2)
- HbA1c point of care \>= 6.5%
- Kidney disease
- Any known history of an inherited metabolic disorder
- Pregnant or lactating female (pregnancy test will be required)
- Professional or collegiate athlete
- Travel across \>1 time zone within a 3-month period before and during the protocol
- DLMO \> 24:00 will be excluded from the metabolic study visits
Exclusion
Key Trial Info
Start Date :
January 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 19 2025
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT04671797
Start Date
January 15 2021
End Date
June 19 2025
Last Update
June 22 2025
Active Locations (1)
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1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224