Status:
COMPLETED
Treatment Protocols for Patients With Symptomatic Oral Lichen Planus
Lead Sponsor:
University of Messina
Conditions:
Lichen Planus, Oral
Preneoplastic Condition
Eligibility:
All Genders
25-70 years
Phase:
NA
Brief Summary
The primary objective of this study was to compare the therapeutic efficacy of clobetasol propionate 0.05% oral gel versus an anti-inflammatory mouthwash in an oral solution for the management of pati...
Detailed Description
Forty patients were assigned (20 patients per group), through a randomized design, to receive clobetasol (clobetasol gel 0.05%), or an anti-inflammatory mouthwash (mouthwash which contains calcium hyd...
Eligibility Criteria
Inclusion
- age ≥ 18 years;
- clinical diagnosis and histological diagnosis of OLP on the basis of WHO criteria;
- presence of symptoms related to OLP.
Exclusion
- presence of systemic conditions that may have affected the study results;
- state of pregnancy or breastfeeding;
- histological signs of dysplasia;
- drugs inducing a lichen response (ACE-inhibitors, β-blockers, etc.);
- treatment of OLP in the six months prior to the start of the programme;
- presence of extraoral lesions (genital, skin and other)
- history of previous immunodeficiency or HIV seropositivity;
- previous allogeneic bone marrow transplantation;
- presence of systemic lupus erythematosus or other autoimmune diseases.
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 25 2020
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT04673916
Start Date
June 1 2019
End Date
June 25 2020
Last Update
December 17 2020
Active Locations (1)
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1
University of Messina
Messina, Italy, 98100