Status:
UNKNOWN
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Critical Illness
Extracorporeal Membrane Oxygenation Complication
Eligibility:
All Genders
18-90 years
Brief Summary
Observational study Primary Objective: To study whether ECMO alters the PK of anti-infectives including voriconazole, posaconazole and caspofungin in critically ill patients on ECMO Secondary Objecti...
Detailed Description
Anti-infective drug selection and dosing will be at the discretion of the clinician, based on the clinical context and unit guidelines. Doses will be reconstituted and administered as per local hospit...
Eligibility Criteria
Inclusion
- Age \>18 years and \<90 years
- Currently undergoing ECMO for respiratory +/- cardiac dysfunction
- Clinical indication for the anti-infectives, including voriconazole, posaconazole and caspofungin
Exclusion
- History of allergy to any of the study drug
- Pregnant women
Key Trial Info
Start Date :
September 3 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04674657
Start Date
September 3 2018
End Date
September 1 2021
Last Update
December 19 2020
Active Locations (1)
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1
Royal Brompton & Harefield NHS Foundation Trust
Harefield, Middlesex, United Kingdom, UB9 6JH