Status:
UNKNOWN
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Westmead and Blacktown Hospital, Sydney West Radiation Oncology Network, Sydney, Australia
Aarhus University Hospital
Conditions:
Lung Cancer
Radiation-Induced Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radio...
Detailed Description
In this project, a novel method of safe radiotherapy delivery shall be tested for patients with lung cancer in a clinical setting. Functional avoidance radiotherapy is a new method that protect highly...
Eligibility Criteria
Inclusion
- histologically verified lung cancer (small-cell and non-small cell lung cancer)
- referred for radiotherapy with curative intent
- radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard
- concurrent chemotherapy is accepted
- patients with oligometastatic disease are allowed, where metastasis have been ablated with surgery or radiotherapy
- receiving (chemo)-radiotherapy to the thoracic disease with curative intent
- adults over 18, that have given oral and written informed consent before patient registration.
Exclusion
- concurrent immunotherapy
- previous radiotherapy to the thorax
- other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
195 Patients enrolled
Trial Details
Trial ID
NCT04676828
Start Date
December 1 2020
End Date
December 1 2024
Last Update
May 20 2022
Active Locations (2)
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1
Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals
Sydney, New South Wales, Australia, 2145
2
Department of Oncology, Aarhus University Hospital
Aarhus, Denmark, DK-8000